Journal of Clinical Nutrition & Dietetics

Sepsis, Nutriton and Mitochondrial Energetics

The hypermetabolic response during acute inflammation in sepsis is rapidly replaced by a hypometabolic state as the organism struggles to balance severe stress responses of resistance and tolerance. Conceptually, therapeutic targeting of mitochondrial bioenergetic pathways may resolve immune and multi-organ failure and improve survival. Current pre-clinical data are consistent with the postulate that dysfunction of the mitochondrial pyruvate dehydrogenase complex drives many of the immunometabolic complications of severe infection. Targeting this pathway resolves epigenetic, bioenergetic, nutritional, and oxidation/reduction dysregulation in cells and organs and provides survival benefit during the acute immune response.

Author(s):

McCall Charles E, Manal Zabalawi, Barbara K Yoza and Peter S Stacpoole

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