Journal of Clinical Nutrition & Dietetics

Effects of the Avocado Oil Supplementation on Oxidative and Insulin Resistance Parameters in a Double-Blind and Randomized Clinical Trial in Metabolic Syndrome Patients

Background: Metabolic Syndrome (MetS) is a group of comorbidities that increase the risk of developing cardiovascular diseases and appears to be associated with chronic low-grade inflammation and oxidative stress. On the other hand, avocado oil has shown a positive effect in improving oxidative stress, but there is a lack of translation studies focusing on MetS patients. Thus, the present study aimed to evaluate the effects of avocado oil supplementation on oxidative parameters and insulin resistance in obese patients with metabolic syndrome.

Methods: Thirty-three obesity adults, of both genders, diagnosed with MetS, were included and separated into two groups: Control group (n=17) and avocado oil group (n=16). The subjects consumed 10 mL of soybean oil or avocado oil for 3 months and were instructed to maintain their regular medications and normal lifestyle. Anthropometric, insulin resistance markers (fasting blood glucose, fasting blood insulin, glycated hemoglobin A1c and homeostatic model assessment), lipid profile (triglycerides, low-density lipoprotein, high-density lipoprotein and total cholesterol) and oxidative stress parameters were assessed both before and after supplementation.

Results: The mean and standard deviation of all parameters were evaluated. There were no significant differences observed between the pre and post intervention measurements in both the control and avocado oil groups. However, when comparing the post-supplementation measurements between the control and avocado oil groups, higher levels of triglycerides were observed in the avocado oil group.

Conclusion: The dose and duration of avocado oil supplementation used in this study did not affect oxidative stress and insulin resistance parameters in obese individuals with MetS.

Author(s): Erika Lawall Lopes Ramos, Ana Carolina Fernandes Azevedo, Marina Guedes Fraga Lopes, Mario Flávio Cardoso de Lima, Laura de Roch Casagrande, Paulo Cesar Lock Silveira, Ana Paula Boroni Moreira and Claudio Teodoro de Souza

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