Background: Coffee contains thousands of chemical compounds such as chlorogenic acid, caffeine, potassium, niacin, magnesium and tocopherols. Only caffeine in coffee shows pharmacological effects. Based on relevant studies, caffeine in coffee has many side effects such as increasing blood pressure, homocysteine, plasma renin; catecholamine and arrhythmia, which are considered as risk factors for coronary heart diseases (CHD). Several epidemiological studies have investigated this association which conflict each other.
Materials and method: The current research was conducted based on articles published in medical journals from 2000 to 2014 applying the PubMed database from which 56 articles were selected.
Results: According to the research, coffee can affect the risk of myocardial infraction. Furthermore, coffee’s effect on blood pressure depends on the duration of coffee consumption. Coffee can increase homocysteine concentration which is one of the risk factors for coronary heart diseases.
Conclusion: It seems that coffee can affect coronary heart diseases, but these effects depend on many factors too, consisting genetic polymorphism.
Zainab Shateri and Kurosh Djafarian